血管作動性腸管ペプチド
From Wikipedia, the free encyclopedia
VIPは体の部分によって違った効果を持つ。
- 消化器系では、平滑筋を弛緩させ（下部食道括約筋、胃、胆嚢）、膵液と胆汁の分泌を刺激する。そして、胃酸の分泌と腸への吸収が抑制要因となる[1]。腸への役割は水分と電解液の強力な分泌刺激で[2]、腸の平滑筋と血管を膨張させ、膵臓の炭酸水素塩の分泌を刺激し、ガストリンによる胃酸分泌を抑制する。これらの効果はすべて同時に増大する[3]。
- 脳やいくつかの自律神経でもVIPが見つかっている。脳の一部である視交叉上核（SCN）は概日リズムの場所である。ここで血管作動性腸管ペプチドはSCNと脳細胞との間で重要なコミュニケーションの役割を果たしている。また、VIPは明暗サイクルに伴うSCNの機能との連動に関わっている。つまり、VIPとSCNは哺乳類の概日リズムの時計機構に対し重要な役割を担っているのである。
- VIPは幽門括約筋の収縮される作用がある。
病理学
悪性非β膵島細胞腫瘍ではVIPが過剰に生産される[5]。
脚注
[脚注の使い方]
- ↑ Vasoactive Intestinal Peptide
- ↑ GPnotebook;1892679719
- ↑ Anatomy Atlases: Atlas of Microscopic Anatomy: Section 1 - Cells
- ↑ Kulick R, Chaiseha Y, Kang S, Rozenboim I, El Halawani M (2005). “The relative importance of vasoactive intestinal peptide and peptide histidine isoleucine as physiological regulators of prolactin in the domestic turkey”. Gen Comp Endocrinol 142 (3): 267-73. doi:10.1016/j.ygcen.2004.12.024. PMID 15935152.
- 1 2 Vasoactive Intestinal Peptide
参考文献
- Fahrenkrug J (2002). “Gut/brain peptides in the genital tract: VIP and PACAP.”. Scand. J. Clin. Lab. Invest. Suppl. 234: 35-9. PMID 11713978.
- Delgado M, Pozo D, Ganea D (2004). “The significance of vasoactive intestinal peptide in immunomodulation.”. Pharmacol. Rev. 56 (2): 249-90. doi:10.1124/pr.56.2.7. PMID 15169929.
- Conconi MT, Spinazzi R, Nussdorfer GG (2006). “Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland.”. Int. Rev. Cytol. 249: 1-51. doi:10.1016/S0074-7696(06)49001-X. PMID 16697281.
- Hill JM (2007). “Vasoactive intestinal peptide in neurodevelopmental disorders: therapeutic potential.”. Curr. Pharm. Des. 13 (11): 1079-89. doi:10.2174/138161207780618975. PMID 17430171.
- Gonzalez-Rey E, Varela N, Chorny A, Delgado M (2007). “Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator.”. Curr. Pharm. Des. 13 (11): 1113-39. doi:10.2174/138161207780618966. PMID 17430175.
- “[Quaternary structure of rabbit skeletal muscle glycogen synthetase]”. Dokl. Akad. Nauk SSSR 222 (4): 997-1000. (1975). PMID 807467.
- Kitamura K, Kangawa K, Kawamoto M, et al. (1992). “Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.”. Biochem. Biophys. Res. Commun. 185 (1): 134-41. doi:10.1016/S0006-291X(05)80966-0. PMID 1318039.
- Glowa JR, Panlilio LV, Brenneman DE, et al. (1992). “Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist.”. Brain Res. 570 (1-2): 49-53. doi:10.1016/0006-8993(92)90562-N. PMID 1617429.
- Theriault Y, Boulanger Y, St-Pierre S (1991). “Structural determination of the vasoactive intestinal peptide by two-dimensional H-NMR spectroscopy.”. Biopolymers 31 (4): 459-64. doi:10.1002/bip.360310411. PMID 1863695.
- Gozes I, Giladi E, Shani Y (1987). “Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level.”. J. Neurochem. 48 (4): 1136-41. doi:10.1111/j.1471-4159.1987.tb05638.x. PMID 2434617.
- Yamagami T, Ohsawa K, Nishizawa M, et al. (1988). “Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter.”. Ann. N. Y. Acad. Sci. 527: 87-102. PMID 2839091.
- Bodner M, Fridkin M, Gozes I (1985). “Coding sequences for vasoactive intestinal peptide and PHM-27 peptide are located on two adjacent exons in the human genome.”. Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3548-51. doi:10.1073/pnas.82.11.3548. PMID 2987932.
- DeLamarter JF, Buell GN, Kawashima E, et al. (1985). “Vasoactive intestinal peptide: expression of the prohormone in bacterial cells.”. Peptides 6 Suppl 1: 95-102. doi:10.1016/0196-9781(85)90016-6. PMID 2995945.
- Linder S, Barkhem T, Norberg A, et al. (1987). “Structure and expression of the gene encoding the vasoactive intestinal peptide precursor.”. Proc. Natl. Acad. Sci. U.S.A. 84 (2): 605-9. doi:10.1073/pnas.84.2.605. PMID 3025882.
- Gotoh E, Yamagami T, Yamamoto H, Okamoto H (1989). “Chromosomal assignment of human VIP/PHM-27 gene to 6q26----q27 region by spot blot hybridization and in situ hybridization.”. Biochem. Int. 17 (3): 555-62. PMID 3202886.
- Yiangou Y, Di Marzo V, Spokes RA, et al. (1987). “Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide.”. J. Biol. Chem. 262 (29): 14010-3. PMID 3654650.
- Gozes I, Bodner M, Shani Y, Fridkin M (1986). “Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor.”. Peptides 7 Suppl 1: 1-6. doi:10.1016/0196-9781(86)90156-7. PMID 3748844.
- Tsukada T, Horovitch SJ, Montminy MR, et al. (1985). “Structure of the human vasoactive intestinal polypeptide gene.”. DNA 4 (4): 293-300. PMID 3899557.
- Heinz-Erian P, Dey RD, Flux M, Said SI (1985). “Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients.”. Science 229 (4720): 1407-8. doi:10.1126/science.4035357. PMID 4035357.
- Bloom SR, Christofides ND, Delamarter J, et al. (1984). “Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene.”. Lancet 2 (8360): 1163-5. PMID 6139527.
