CXCL17
From Wikipedia, the free encyclopedia
| chemokine (C-X-C motif) ligand 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CXCL17 | ||||||
| Alt. symbols | SCYB17, VCC-1, DMC | ||||||
| NCBI gene | 284340 | ||||||
| RefSeq | NM_198477 | ||||||
| UniProt | Q6UXB2 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.2 | ||||||
| |||||||
Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine initially thought to belong to the CXC chemokine family, then addressed as chemokine-like protein, that has been identified in humans and mice.
CXCL17 has been previously reported to attract dendritic cells and monocytes, but there are also studies not reporting this activity;[1] it is also regulated in tumors. It was formerly known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).[2][3] This chemokine is constitutively expressed in the respiratory tract and more specifically in the lung.[3] The gene for human CXCL17 is located on chromosome 19.[3] Human and murine CXCL17 protein share 71% of amino acid sequence identity.[4]
Doubt has been expressed that CXCL17 should truly be considered a member of the chemokine ligand family and it has therefore been described as a "Black Sheep".[5]
