Flubatine

Flubatine
Identifiers
	IUPAC name (1R,5S,6S)-6-(6-(18F)fluoranylpyridin-3-yl)-8-azabicyclo[3.2.1]octane;
CAS Number	1012885-77-6;
PubChem CID	71724875;
ChemSpider	129434972;
UNII	CN2ULA1988;
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES C1C[C@@H]2C[C@H]([C@H](C1)N2)C3=CN=C(C=C3)[18F];
	InChI InChI=1S/C12H15FN2/c13-12-5-4-8(7-14-12)10-6-9-2-1-3-11(10)15-9/h4-5,7,9-11,15H,1-3,6H2/t9-,10+,11+/m1/s1/i13-1; Key:FDFUKZJWVPEZEH-MEPPPMTQSA-N;

Flubatine ([18F]-norchloro-fluoro-homoepibatidine) is a fluorine-18 (¹⁸F) labeled radiotracer and radioligand for positron emission tomography (PET) imaging, developed as a high-affinity ligand for brain nicotinic acetylcholine receptors (nAChRs) of the α4β2 subtype.^[2]^[3] It is used to image cholinergic deficits in disorders such as Alzheimer’s disease and Parkinson’s disease.^[4] Both (+)- and (−)- enantiomer bind specifically to α4β2 nAChRs.^[5]

References

Identifiers

IUPAC name (1R,5S,6S)-6-(6-(18F)fluoranylpyridin-3-yl)-8-azabicyclo[3.2.1]octane
CAS Number	1012885-77-6^[1]
PubChem CID	71724875
ChemSpider	129434972
UNII	CN2ULA1988
Chemical and physical data
3D model (JSmol)	Interactive image
SMILES C1C[C@@H]2C[C@H]([C@H](C1)N2)C3=CN=C(C=C3)[18F]
InChI InChI=1S/C12H15FN2/c13-12-5-4-8(7-14-12)10-6-9-2-1-3-11(10)15-9/h4-5,7,9-11,15H,1-3,6H2/t9-,10+,11+/m1/s1/i13-1 Key:FDFUKZJWVPEZEH-MEPPPMTQSA-N