HLA-B47
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major histocompatibility complex (human), class I, B47 | ||
| Alleles | B*4701 B*4702 B*4703 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*4701 | |
| EBI-HLA | B*4702 | |
| EBI-HLA | B*4703 | |
| Locus | chr.6 6p21.31 | |
HLA-B47 (B47) is an HLA–B serotype. The serotype identifies the HLA-B*47 gene products (B*4701, B*4702, B*4703) .[1] Comparison of B47 nucleotide sequence with other HLA-B sequences shows a segment of 228 bp identical with B44 in the alpha 1 domain and a segment of 218 bp identical with B27 in the alpha 2 domain, but only a 91 bp segment of identity with B13 in the alpha 1 domain. The complex pattern of substitutions and their degree of divergence indicate that HLA-B13 and HLA-Bw47 alleles are not related by a simple mutational event.[2] B47 is linked to (close to on the chromosome) a gene that causes adrenal deficiency. B47 is generally low in frequency and with highest known frequencies in Central and Western Africa. (For terminology help see: HLA-serotype tutorial)
| B*47 | B47 | Other | Sample |
| allele | % | % | size (N) |
| 4701 | 50 | 37 | 317 |
| 4702 | 40 | 40 | 5 |
| 4703 | 25 | 50 | 4 |
Serotyping for B47 is poor and typing is best performed with SSP-PCR or gene sequencing.
