HLA-B53
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major histocompatibility complex (human), class I, B53 | ||
| Alleles | B*5301 B*5302 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*5301 | |
| EBI-HLA | B*5302 | |
| Locus | chr.6 6p21.31 | |
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)
| B*53 | B53 | B35 | Sample |
| allele | % | % | size (N) |
| 5301 | 86 | 5 | 3054 |
| 5302 | 80 | 20 | 5 |