HLA-B52
Human leukocyte antigen serotype
From Wikipedia, the free encyclopedia
HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.[1]
 | ||
| B*5101-β2MG with bound peptide 1e27 | ||
major histocompatibility complex (human), class I, B52 | ||
| Alleles | B*5201, 5202, 5203, . . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101.[2] There are a number of alleles within the B*52 allele group.[3]
Serotype
| B*52 | B52 | B5 | B51 | B53 | Sample |
| allele | % | % | % | % | size (N) |
| *5201 | 84 | 2 | 7 | 1 | 2823 |
| Alleles link-out to IMGT/HLA Databease at EBI | |||||
| freq | ||
| ref. | Population | (%) |
| [5] | China Yunnan Lisu | 21.7 |
| [5] | China Yunnan Nu | 18.6 |
| [5] | Bulgaria Gipsy | 18.2 |
| [5] | Venezuela Sierra de Perija Yucpa | 12.8 |
| [5] | India Andhra Pradesh Golla | 12.0 |
| [5] | Japan Central | 10.7 |
| [5] | Japan | 10.4 |
| [5] | Georgia Tbilisi Kurds | 10.3 |
| [5] | Mali Bandiagara | 8.3 |
| [5] | South Africa Natal Tamil | 8.2 |
| [5] | Israel Ashk. and Non-Ashk. Jews | 7.3 |
| [5] | India North Hindus | 6.7 |
| [5] | China Beijing | 6.1 |
| [5] | India New Delhi | 6.1 |
| [5] | India Mumbai Marathas | 5.6 |
| [5] | Tunisia Ghannouch | 5.5 |
| [5] | Thailand pop3 | 5.1 |
| [5] | India West Coast Parsis | 5.0 |
| [5] | India North Delhi | 4.9 |
| [5] | Mexico Mestizos | 4.9 |
| [5] | Argentina Toba Rosario | 4.7 |
| [5] | Mexico Zaptotec Oaxaca | 4.5 |
| [5] | USA Hispanic | 4.5 |
| [5] | China Qinghai Hui | 4.1 |
| [5] | China Inner Mongolia | 3.9 |
| [5] | China North Han | 3.8 |
| [5] | Oman | 3.8 |
| [5] | Senegal Niokholo Mandenka | 3.7 |
| [5] | Bulgaria | 3.6 |
| [5] | Thailand | 3.5 |
| [5] | Ivory Coast Akan Adiopodoume | 3.4 |
| [5] | Venezuela Perja Mountain Bari | 3.4 |
| [5] | Italy North pop 1 | 3.3 |
| [5] | Sudanese | 3.3 |
| [5] | Romanian | 3.2 |
| [5] | Singapore Riau Malay | 3.0 |
| [5] | Autonomous Region Tibetans | 2.8 |
| [5] | Russia Tuva pop 2 | 2.8 |
| [5] | South Korea pop 3 | 2.8 |
| [5] | Iran Baloch | 2.5 |
| [5] | Tunisia | 2.5 |
| [5] | Jordan Amman | 2.4 |
| [5] | USA Hawaii Okinawa | 2.4 |
| [5] | Singapore Javanese Indonesians | 2.0 |
| [5] | Spain Eastern Andalusia | 1.8 |
| [5] | Macedonia pop 4 | 1.6 |
| [5] | Uganda Kampala | 1.6 |
| [5] | Belgium | 1.5 |
| [5] | Mexico Guadalajara Mestizos pop2 | 1.5 |
| [5] | Singapore Thai | 1.5 |
| [5] | Brazil | 1.4 |
| [5] | China Yunnan Lisu | 1.4 |
| [5] | Azores Santa Maria and Sao Miguel | 1.3 |
| [5] | France South East | 1.2 |
| [5] | Italy North Pavia | 1.2 |
| [5] | Saudi Arabia Guraiat and Hail | 1.2 |
| [5] | Mexico Chihuahua State Tarahumara | 1.1 |
| [5] | Tunisia Tunis | 1.1 |
| [5] | Israel Arab Druse | 1.0 |
| [5] | Japan Ainu Hokkaido | 1.0 |
| [5] | Portugal Centre | 1.0 |
| [5] | Singapore Chinese | 1.0 |
| [5] | Taiwan Minnan pop 1 | 1.0 |
| [5] | USA Caucasian | 1.0 |
| [5] | Azores Central Islands | 0.9 |
| [5] | China South Han | 0.9 |
| [5] | Macedonia pop 4 | 0.7 |
| [5] | Morocco Nador Metalsa Class I | 0.7 |
| [5] | Georgia Svaneti Svans | 0.6 |
| [5] | Ireland South | 0.6 |
| [5] | Italy Bergamo | 0.6 |
Alleles
There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.
Disease
In ulcerative colitis
HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.[6][7] This form of disease is frequently found with Takayasu's arteritis.[8][9]
In Takayasu's arteritis
Takayasu's arteritis appears to have an independent link to B52 associated disease.[10][11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.[12]