MFZ 10-7

CAS Number

• 1224431-15-5

ChemSpider

• 26334163

UNII

• FV36HKQ9RA

ChEMBL

• ChEMBL1784608

MFZ 10-7

Identifiers
IUPAC name 3-Fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile
CAS Number	1224431-15-5
ChemSpider	26334163
UNII	FV36HKQ9RA
ChEMBL	ChEMBL1784608
CompTox Dashboard (EPA)	DTXSID501336029
Chemical and physical data
Formula	C15H9FN2
Molar mass	236.244
3D model (JSmol)	Interactive image
SMILES Cc1cccc(n1)C#Cc2cc(cc(c2)F)C#N
InChI InChI=1S/C15H9FN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3 Key:ZGEXQIMQZVRTDZ-UHFFFAOYSA-N

MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a drug with potential applications in the treatment of addiction, which acts as a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP and MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.^[1]