ML2-SA1

ML2-SA1
Identifiers
	IUPAC name 5-(2,6-dichlorophenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene;
CAS Number	2349386-89-4;
PubChem CID	137553170;
IUPHAR/BPS	10301;
ChemSpider	84400411;
UNII	9Y7K335ZQY;
CompTox Dashboard (EPA)	DTXSID201336632 ;
Chemical and physical data
Formula	C14H13Cl2NO
Molar mass	282.16 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4cccc(Cl)c4C3=NOC2C1CC(CC1)C23;
	InChI InChI=1S/C14H13Cl2NO/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14H,4-6H2; Key:NBXVMFMMTKYFQP-UHFFFAOYSA-N;

ML2-SA1 (EVP-22) is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML2 calcium channel, with high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels. It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2 from macrophages and stimulating macrophage migration and endolysosomal trafficking.^[1]^[2]

[1]

[2]

ML2-SA1

References

Related Articles

Identifiers

IUPAC name 5-(2,6-dichlorophenyl)-3-oxa-4-azatricyclo[5.2.1.0^2,6]dec-4-ene
CAS Number	2349386-89-4
PubChem CID	137553170
IUPHAR/BPS	10301
ChemSpider	84400411
UNII	9Y7K335ZQY
CompTox Dashboard (EPA)	DTXSID201336632
Chemical and physical data
Formula	C₁₄H₁₃Cl₂NO
Molar mass	282.16 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc4cccc(Cl)c4C3=NOC2C1CC(CC1)C23
InChI InChI=1S/C14H13Cl2NO/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14H,4-6H2 Key:NBXVMFMMTKYFQP-UHFFFAOYSA-N