MN1 (gene)

The translocation of MN1 was first reported in meningioma.^[5] A substantial percentage of primitive neuro-ectodermal tumors (PNET) have MN1 translocations^[10] Several different partners were described, although in many cases no fusion partner was identified. MN1 transloations also occur in up to 2% of acute myeloid leukemia (AML)^[11] Described fusion partners include ETV6, STAT3 and FLI1.^[12][11][13] About 50% of fusions are out of frame and result in high expression of MN1 via enhancer hijacking.^[11][6] High MN1 expression in AML and MDS is associated with poor outcome ^{[14][15][16][17][18][19][20][excessive citations]}

Mutations in this gene have been associated with cleft palate^[21][22][23] and an atypical form of rhombencephalosynapsis.^[24]