Oxazepam hemisuccinate

Trade namesEmpracil

CAS Number

• 4700-56-5

PubChem CID

• 36754

CompTox Dashboard (EPA)

• DTXSID70924562

Oxazepam hemisuccinate

Clinical data
Trade names	Empracil
Identifiers
IUPAC name 4-[(7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)oxy]-4-oxobutanoic acid
CAS Number	4700-56-5
PubChem CID	36754
CompTox Dashboard (EPA)	DTXSID70924562
ECHA InfoCard	100.022.886
Chemical and physical data
Formula	C19H15ClN2O5
Molar mass	386.79 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)OC(=O)CCC(=O)O
InChI InChI=1S/C19H15ClN2O5/c20-12-6-7-14-13(10-12)17(11-4-2-1-3-5-11)22-19(18(26)21-14)27-16(25)9-8-15(23)24/h1-7,10,19H,8-9H2,(H,21,26)(H,23,24) Key:UCUOKZUJHTYPJT-UHFFFAOYSA-N

Oxazepam hemisuccinate (Empracil), is a benzodiazepine derivative which is an ester substituted prodrug of oxazepam. It was developed as a water-soluble benzodiazepine suitable for administration by injection, for use as an anxiolytic and for procedural sedation. It was used medically to a limited extent during the 1970s and 1980s under the brand name Empracil, but fell into disuse following the introduction of midazolam, which is similarly water-soluble and is more potent and effective than oxazepam hemisuccinate for the same medical applications. It has two isomers, with the R enantiomer being more effective due to more efficient cleavage of the ester link.^{[1][2][3][4][5][6]}