PRIM1

DNA primase small subunit is in humans is encoded by the PRIM1 gene and is part of the enzyme DNA polymerase alpha.^[5]

PDBOrtholog search: PDBe RCSB

AliasesPRIM1, p49, primase (DNA) subunit 1, DNA primase subunit 1

External IDsOMIM: 176635; MGI: 97757; HomoloGene: 730; GeneCards: PRIM1; OMA:PRIM1 - orthologs

Chr.Chromosome 12 (human)^[1]

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PRIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BPU, 4BPW, 4BPX, 4LIK, 4LIL, 4MHQ, 4RR2, 5EXR
Identifiers
Aliases	PRIM1, p49, primase (DNA) subunit 1, DNA primase subunit 1
External IDs	OMIM: 176635; MGI: 97757; HomoloGene: 730; GeneCards: PRIM1; OMA:PRIM1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,731,296 bp[1] End 56,752,374 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 76.39 cM|10 D3 Start 127,851,037 bp[2] End 127,865,906 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle ganglionic eminence ventricular zone bone marrow bone marrow cell rectum Achilles tendon lymph node islet of Langerhans Top expressed in medial ganglionic eminence fetal liver hematopoietic progenitor cell genital tubercle vas deferens maxillary prominence primitive streak mandibular prominence internal carotid artery condyle tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity transferase activity nucleotidyltransferase activity metal ion binding single-stranded DNA binding DNA primase activity Cellular component membrane nucleoplasm alpha DNA polymerase:primase complex primosome complex Biological process DNA replication G1 phase DNA replication initiation DNA replication, synthesis of RNA primer telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5557 19075 Ensembl ENSG00000198056 ENSMUSG00000025395 UniProt P49642 P20664 RefSeq (mRNA) NM_000946 NM_008921 RefSeq (protein) NP_000937 NP_032947 Location (UCSC) Chr 12: 56.73 – 56.75 Mb Chr 10: 127.85 – 127.87 Mb PubMed search [3] [4]
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The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit.