Prednisolone acetate

From Wikipedia, the free encyclopedia

Other namesPrednisolone 21-acetate
Drug classCorticosteroid; Glucocorticoid
CAS Number
PubChem CID
Prednisolone acetate
Clinical data
Other namesPrednisolone 21-acetate
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
CAS Number
PubChem CID
DrugBank
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.123 Edit this at Wikidata
Chemical and physical data
FormulaC23H30O6
Molar mass402.487 g·mol−1
3D model (JSmol)
Melting point240 °C (464 °F)
  • CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)O
  • InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
  • Key:LRJOMUJRLNCICJ-JZYPGELDSA-N

Prednisolone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the 21-acetate ester of prednisolone.[1][2]

Prednisolone acetate is acutely toxic with an LD50 of >240 mg/kg for a rat and 3500 mg/kg for a mouse. Effects may present delayed. Target organs include adrenal cortex, bones, and eyes. It is also a known teratogen.[3] Class B PPE should be worn when working with this chemical. Any contact with this chemical should be taken seriously and the affected person taken to the hospital.

Overdose

Physical properties

References

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