MECP2

MECP2
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1QK9, 3C2I
Identifiants
Alias	MECP2
IDs externes	OMIM: 300005 MGI: 99918 HomoloGene: 3657 GeneCards: MECP2
Position du gène (humain)
Chr.	Chromosome X
Fin	154,137,103 bp
Position du gène (souris)
Chr.	X chromosome (souris)
Fin	73,178,969 bp
Expression génique
	Fortement exprimé dans
	paraflocculus of cerebellum; ; Brodmann area 10; ; nerf sural; ; frontal pole; ; epithelium of colon; ; gyrus frontal moyen; ; Vermis du cervelet; ; tendon calcanéen; ; gyrus postcentral; ; sang;
	Fortement exprimé dans
	substantia nigra; ; Rostral migratory stream; ; glande pinéale; ; habenula; ; dorsal striatum; ; Region I of hippocampus proper; ; anterior amygdaloid area; ; colliculus supérieur; ; corps ciliaire; ; lateral septal nucleus;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	double-stranded methylated DNA binding; transcription corepressor activity; protein domain specific binding; protein N-terminus binding; DNA-binding transcription factor activity; transcription factor binding; liaison pARNi; liaison ARNm; liaison de chromatine; liaison protéique; liaison ADN; DNA-binding transcription repressor activity, RNA polymerase II-specific; liaison ARN; methyl-CpG binding;
Composant cellulaire	postsynapse; cytoplasme; mitochondrie; noyau; hétérochromatine; milieu extracellulaire; gamma-tubulin complex; centrosome; cytosol; chromatine; nucléoplasme;
Processus biologique	negative regulation of neuron apoptotic process; multicellular organismal response to stress; inositol metabolic process; mitochondrial electron transport, ubiquinol to cytochrome c; développement postembryonnaire; apprentissage; proprioception; neuron projection development; regulation of gene expression by genetic imprinting; regulation of transcription, DNA-templated; pathogenèse; neuromuscular process controlling posture; adult locomotory behavior; mémoire; transcription, DNA-templated; ventricular system development; neuron maturation; régulation positive de la transcription dépendante de l'ADN; glutamine metabolic process; neuromuscular process; histone acetylation; Potentiel postsynaptique excitateur; nervous system process involved in regulation of systemic arterial blood pressure; comportement social; Synaptogenèse; transmission synaptique chimique; negative regulation of histone methylation; réflexe de sursaut acoustique; glucocorticoid metabolic process; synthèse des dentrites; negative regulation of transcription by RNA polymerase II; behavioral fear response; respiratory gaseous exchange by respiratory system; cerebellum development; regulation of synaptic plasticity; cardiolipin metabolic process; différenciation d'un neurone; régulation de l'expression des gènes; nociception; negative regulation of transcription, DNA-templated; phosphatidylcholine metabolic process; visual learning; protein localization; response to hypoxia; regulation of gene expression, epigenetic; cellular biogenic amine metabolic process; regulation of respiratory gaseous exchange by nervous system process; développement cérébral; mémoire à long terme; histone methylation; negative regulation of histone acetylation; catecholamine secretion; potentialisation à long terme; positive regulation of synapse assembly; negative regulation of smooth muscle cell differentiation; positive regulation of histone H3-K9 trimethylation; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; mitotic spindle organization; locomotory behavior; positive regulation of cell population proliferation; response to radiation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of microtubule nucleation; transcription initiation from RNA polymerase II promoter; negative regulation of gene expression; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; positive regulation of DNA methylation;
	Sources:Amigo / QuickGO
Orthologues
	4204
	17257
	ENSG00000169057
	ENSMUSG00000031393
	P51608
	Q9Z2D6
NM_001110792; NM_004992; NM_001316337; NM_001369391; NM_001369392;
	NM_001369393; NM_001369394; NM_001386137; NM_001386138; NM_001386139
	NM_001081979; NM_010788
NP_001104262; NP_001303266; NP_004983; NP_001356320; NP_001356321;
	NP_001356322; NP_001356323
	NP_001075448; NP_034918
	Wikidata
Voir/Editer Humain	Voir/Editer Souris