Chloride channel blocker
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Type of drug
A chloride channel blocker is a type of drug which inhibits the transmission of ions (Cl−) through chloride channels.
Niflumic acid is a chloride channel blocker that has been used in experimental scientific research.[1] Another example is anthracene-9-carboxylic acid, a potent blocker of the CLCN1-type chloride channel found in skeletal muscle, which is used to study animal models of myotonia congenita.[2]
Some antagonists of glycine receptors and GABAA receptors also act as chloride channel blockers.
References
- ↑ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
- ↑ Villegas-Navarro A, Martinez-Morales M, Morales-Aguilera A (March 1986). "Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer". Archives Internationales de Pharmacodynamie et de Thérapie. 280 (1): 5–21. PMID 3718080.
Further reading
- Phillis JW, Song D, O'Regan MH (January 1998). "Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex". Brain Research. 780 (2): 352–5. doi:10.1016/S0006-8993(97)01352-8. PMID 9507191. S2CID 3160962.
- Zhou, Yuhong; Shapiro, Michael; Dong, Qu; Louahed, Jamila; Weiss, Christine; Wan, Shanhong; Chen, Qiming; Dragwa, Carl; Savio, Dawn; Huang, Minxue; Fuller, Catherine; Tomer, Yaniv; Nicolaides, Nicholas C.; McLane, Michael; Levitt, Roy C. (2002). "A Calcium-Activated Chloride Channel Blocker Inhibits Goblet Cell Metaplasia and Mucus Overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–170. doi:10.1002/0470860790.ch10. ISBN 9780470844786.
- Mohamed F, Senarathna L, Percy A, Abeyewardene M, Eaglesham G, Cheng R, Azher S, Hittarage A, Dissanayake W, Sheriff MH, Davies W, Buckley NA, Eddleston M (2004). "Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil--a GABAA-gated chloride channel blocker". Journal of Toxicology. Clinical Toxicology. 42 (7): 955–63. doi:10.1081/CLT-200041784. PMC 1351141. PMID 15641641.
- Lukacs GL, Nanda A, Rotstein OD, Grinstein S (August 1991). "The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells". FEBS Letters. 288 (1–2): 17–20. Bibcode:1991FEBSL.288...17L. doi:10.1016/0014-5793(91)80992-C. PMID 1652470. S2CID 35959479.
- Kang JX, Man SF, Brown NE, Labrecque PA, Clandinin MT (August 1992). "The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells". The Biochemical Journal. 285 ( Pt 3) (3): 725–9. doi:10.1042/bj2850725. PMC 1132855. PMID 1323271.
- Liu J, Lai ZF, Wang XD, Tokutomi N, Nishi K (April 1998). "Inhibition of sodium current by chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) in guinea pig cardiac ventricular cells". Journal of Cardiovascular Pharmacology. 31 (4): 558–67. doi:10.1097/00005344-199804000-00014. PMID 9554805.
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