Myotubularin
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| Myotubularin-related | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of a phosphoinositide phosphatase.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Myotub-related | ||||||||
| Pfam | PF06602 | ||||||||
| InterPro | IPR010569 | ||||||||
| SCOP2 | 1m7r / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 130 | ||||||||
| OPM protein | 1zvr | ||||||||
| |||||||||
Myotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate.[2] Mutations in gene encoding myotubularin-related proteins have been associated with disease.[3]