PF-3845

ATC code

• None

Legal status

• US: Investigational New Drug

CAS Number

• 1196109-52-0

PubChem CID

• 25154867

PF-3845

Clinical data
ATC code	None
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name N-3-pyridinyl-4-([3-([5-(trifluoromethyl)-2-pyridinyl]oxy)phenyl]methyl)-1-piperidinecarboxamide
CAS Number	1196109-52-0
PubChem CID	25154867
ChemSpider	26232165
UNII	Q3PW846TYN
CompTox Dashboard (EPA)	DTXSID40648905
Chemical and physical data
Formula	C24H23F3N4O2
Molar mass	456.469 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(NC1=CN=CC=C1)N(CC2)CCC2CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3
InChI InChI=1S/C24H23F3N4O2/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20/h1-7,10,14-17H,8-9,11-13H2,(H,30,32) Key:NBOJHRYUGLRASX-UHFFFAOYSA-N

PF-3845 is a selective inhibitor of fatty acid amide hydrolase.^[1] It results in increased levels of anandamide and results in cannabinoid receptor-based effects. It has anti-inflammatory action in mice colitis models. Antidiarrheal and antinociceptive effects were also seen in mouse models of pain.^[2]

A 2017 study published in the Journal of Psychiatry and Neuroscience found that PF-3845 exerts rapid and long-lasting anti-anxiety effects in mice exposed acutely to stress or chronically to the stress hormone corticosterone.^[3]