URB754

Chemical compound From Wikipedia, the free encyclopedia

URB754 was originally reported by Piomelli et al. to be a potent, noncompetitive inhibitor of monoacylglycerol lipase (MGL).[1] However, recent studies have shown that URB754 failed to inhibit recombinant MGL, and brain FAAH activity was also resistant to URB754.[2] In a later study by Piomelli et al., the MGL-inhibitory activity attributed to URB754 is in fact due to a chemical impurity present in the commercial sample, identified as bis(methylthio)mercurane.[3]

Quick facts Names, Identifiers ...
URB754
Names
Preferred IUPAC name
6-Methyl-2-(4-methylanilino)-4H-3,1-benzoxazin-4-one
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.236.075 Edit this at Wikidata
UNII
  • InChI=1S/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18) ☒N
    Key: GFWNGVKCDGYFKG-UHFFFAOYSA-N ☒N
  • InChI=1/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)
    Key: GFWNGVKCDGYFKG-UHFFFAOYAI
  • CC1=CC=C(C=C1)NC2=NC3=C(C=C(C=C3)C)C(=O)O2
Properties
C16H14N2O2
Molar mass 266.300 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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