O-2050

O-2050 is a drug that is a classical cannabinoid derivative, which acts as an antagonist for the CB₁ receptor. This gives it an advantage in research over many commonly used cannabinoid antagonists, such as rimonabant, which at higher doses act as inverse agonists at CB₁ as well as showing off-target effects. However, while O-2050 acts as a silent antagonist in vitro, some tests in vivo have suggested it may show agonist activity under certain circumstances.^{[1][2][3][4][5][6]}

CAS Number

• 667419-91-2 ^N

PubChem CID

• 16102146

ChemSpider

• 17260023

CompTox Dashboard (EPA)

• DTXSID101030510

Quick facts Identifiers, CAS Number ...

O-2050

Identifiers
IUPAC name (6aR,10aR)-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
CAS Number	667419-91-2 N
PubChem CID	16102146
ChemSpider	17260023
CompTox Dashboard (EPA)	DTXSID101030510
Chemical and physical data
Formula	C23H31NO4S
Molar mass	417.56 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC[C@@H]2[C@@H](C1)c3c(cc(cc3OC2(C)C)CC#CCCCNS(=O)(=O)C)O
InChI InChI=1S/C23H31NO4S/c1-16-10-11-19-18(13-16)22-20(25)14-17(15-21(22)28-23(19,2)3)9-7-5-6-8-12-24-29(4,26)27/h10,14-15,18-19,24-25H,6,8-9,11-13H2,1-4H3/t18-,19-/m1/s1 Key:DJTGGIYZQHHLGJ-RTBURBONSA-N
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