PF-514273

PF-514273
Identifiers
	IUPAC name 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one;
CAS Number	851728-60-4 ;
PubChem CID	11316919;
ChemSpider	9491886 ;
UNII	45FRJ4YGM2;
CompTox Dashboard (EPA)	DTXSID80462142 ;
Chemical and physical data
Formula	C21H17Cl2F2N3O2
Molar mass	452.28 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(CC(F)(C)F)CCOc2c1nn(c2-c(cc4)ccc4Cl)-c3ccccc3Cl;
	InChI InChI=1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3; Key:FJMQJSUOOGOWBD-UHFFFAOYSA-N;
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PF-514273 is a drug developed by Pfizer, which acts as an extremely selective antagonist for the CB₁ receptor, with approximately 10,000x selectivity over the closely related CB₂ receptor. This very high selectivity makes it useful for scientific research into these receptors, as many commonly used cannabinoid receptor antagonists also block the CB₂ receptor to some extent.^[1]

CAS Number

851728-60-4^Y

PubChem CID

11316919

ChemSpider

9491886^N

UNII

45FRJ4YGM2

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PF-514273

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Identifiers

IUPAC name 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
CAS Number	851728-60-4^Y
PubChem CID	11316919
ChemSpider	9491886^N
UNII	45FRJ4YGM2
CompTox Dashboard (EPA)	DTXSID80462142
Chemical and physical data
Formula	C₂₁H₁₇Cl₂F₂N₃O₂
Molar mass	452.28 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1N(CC(F)(C)F)CCOc2c1nn(c2-c(cc4)ccc4Cl)-c3ccccc3Cl
InChI InChI=1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3 Key:FJMQJSUOOGOWBD-UHFFFAOYSA-N
^NY (what is this?)