VCHSR

CAS Number

• 913624-85-8 ^Y

PubChem CID

• 66887337

ChemSpider

• 21378331

ChEMBL

• ChEMBL386832

VCHSR

Identifiers
IUPAC name 5-(4-chlorophenyl)- 3-[(E)-2-cyclohexylethenyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole
CAS Number	913624-85-8 Y
PubChem CID	66887337
ChemSpider	21378331
ChEMBL	ChEMBL386832
Chemical and physical data
Formula	C24H23Cl3N2
Molar mass	445.81 g·mol−1
3D model (JSmol)	Interactive image
SMILES C4CCCCC4C=Cc(c(C)c1-c(cc3)ccc3Cl)nn1-c2ccc(Cl)cc2Cl
InChI InChI=1S/C24H23Cl3N2/c1-16-22(13-7-17-5-3-2-4-6-17)28-29(23-14-12-20(26)15-21(23)27)24(16)18-8-10-19(25)11-9-18/h7-15,17H,2-6H2,1H3/b13-7+ Key:UMOLSRBHNLXWGD-NTUHNPAUSA-N
(verify)

VCHSR is a drug used in scientific research which acts as a selective antagonist of the cannabinoid receptor CB₁. It is derived from the widely used CB₁ antagonist rimonabant, and has similar potency and selectivity for the CB₁ receptor, but has been modified to remove the hydrogen bonding capability in the C-3 substituent region, which removes the inverse agonist effect that rimonabant produces at high doses, so that VCHSR instead acts as a neutral antagonist, blocking the receptor but producing no physiological effect of its own.^[1][2]