Rosterolone

Rosterolone (INNTooltip International Nonproprietary Name) (developmental code name SH-434), also known as 17α-propylmesterolone or 1α-methyl-17α-propyl-5α-androstan-17β-ol-3-one, is a steroidal antiandrogen which was first described in 1984 and was developed for topical administration but was never marketed.^[1][2] It has shown some efficacy in the treatment of acne, and lacks systemic effects with either topical or systemic administration.^[3][1][2] Rosterolone is a derivative of mesterolone, which, in contrast, is an androgen and anabolic steroid.^{[citation needed]}

Other namesSH-434; 17α-Propylmesterolone; 17β-Hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one

Routes of
administrationTopical

CAS Number

• 79243-67-7

PubChem CID

• 71232

Quick facts Clinical data, Other names ...

Rosterolone

Clinical data
Other names	SH-434; 17α-Propylmesterolone; 17β-Hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one
Routes of administration	Topical
Identifiers
IUPAC name (1S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-17-propyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number	79243-67-7
PubChem CID	71232
ChemSpider	64367
UNII	3L5C5C8ZNG
ChEMBL	ChEMBL2107498
CompTox Dashboard (EPA)	DTXSID801033022
ECHA InfoCard	100.071.904
Chemical and physical data
Formula	C23H38O2
Molar mass	346.555 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCC1(CCC2C1(CCC3C2CCC4C3(C(CC(=O)C4)C)C)C)O
InChI InChI=1S/C23H38O2/c1-5-10-23(25)12-9-19-18-7-6-16-14-17(24)13-15(2)22(16,4)20(18)8-11-21(19,23)3/h15-16,18-20,25H,5-14H2,1-4H3/t15-,16-,18-,19-,20-,21-,22-,23-/m0/s1 Key:IMFNBOMNWHWKQD-MXENSADDSA-N

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