2023 Challenger Santa Fe

Country	Player	Rank1	Seed
ARG	Mariano Navone	190	1
ARG	Santiago Rodríguez Taverna	228	2
ARG	Román Andrés Burruchaga	238	3
ARG	Francisco Comesaña	242	4
BRA	Gustavo Heide	338	5
BRA	Eduardo Ribeiro	344	6
PER	Nicolás Álvarez	405	7
BRA	Pedro Boscardin Dias	414	8
ARG	Matías Franco Descotte	426	9

• ¹ Rankings are as of 26 June 2023.^[1]

The following players received wildcards into the singles main draw:

• Alejo Lorenzo Lingua Lavallén
• Juan Ignacio Londero
• Lucio Ratti

The following players received entry into the singles main draw as alternates:

• Preston Brown
• Juan Manuel La Serna

The following players received entry from the qualifying draw:

• Lautaro Corthey
• Igor Gimenez
• Álvaro Guillén Meza
• Luciano Tacchi
• Daniel Vallejo
• Nicolás Villalón

The following player received entry as a lucky loser:

• Ignacio Carou

• Mariano Navone def. Daniel Vallejo 6–2, 6–4.

• Vasil Kirkov / Matías Soto def. Ignacio Carou / Ignacio Monzón 7–6^(7–3), 6–2.