2023 Challenger de Santiago

Country	Player	Rank1	Seed
CHI	Nicolás Jarry	87	1
ITA	Marco Cecchinato	91	2
ARG	Facundo Bagnis	94	3
BOL	Hugo Dellien	96	4
ARG	Juan Manuel Cerúndolo	108	5
ARG	Camilo Ugo Carabelli	122	6
ITA	Franco Agamenone	164	7
ARG	Facundo Díaz Acosta	171	8

• ¹ Rankings are as of 27 February 2023.^[1]

The following players received wildcards into the singles main draw:

• Gonzalo Lama
• Matías Soto
• Nicolás Villalón

The following players received entry from the qualifying draw:

• Daniel Dutra da Silva
• Federico Gaio
• Hugo Gaston
• Álvaro López San Martín
• Thiago Seyboth Wild
• Juan Bautista Torres

The following players received entry as lucky losers:

• João Lucas Reis da Silva
• Gonzalo Villanueva

• Hugo Dellien def. Thiago Seyboth Wild 3–6, 6–3, 6–3.

• Pedro Boscardin Dias / João Lucas Reis da Silva def. Diego Hidalgo / Cristian Rodríguez 6–4, 3–6, [10–7].