2023 Uruguay Open

Country	Player	Rank1	Seed
ARG	Pedro Cachin	68	1
ARG	Federico Coria	88	2
CHI	Tomás Barrios Vera	105	3
ARG	Facundo Díaz Acosta	106	4
CHI	Alejandro Tabilo	109	5
BOL	Hugo Dellien	111	6
ARG	Thiago Agustín Tirante	119	7
ARG	Francisco Comesaña	122	8

• ¹ Rankings are as of 6 November 2023.^[1]

The following players received wildcards into the singles main draw:

• Joaquín Aguilar Cardozo
• Ignacio Carou
• Franco Roncadelli

The following players received entry from the qualifying draw:

• Murkel Dellien
• Álvaro Guillén Meza
• Max Houkes
• Orlando Luz
• Santiago Rodríguez Taverna
• Pedro Sakamoto

The following player received entry as a lucky loser:

• Renzo Olivo

• Facundo Díaz Acosta def. Thiago Monteiro 6–3, 4–3 ret.

• Guido Andreozzi / Guillermo Durán def. Boris Arias / Federico Zeballos 2–6, 7–6^(7–2), [10–8].