2025 Mexico City Open

Country	Player	Rank1	Seed
AUS	James Duckworth	89	1
ARG	Thiago Agustín Tirante	111	2
FRA	Adrian Mannarino	144	3
BRA	Felipe Meligeni Alves	152	4
ARG	Juan Pablo Ficovich	155	5
CAN	Alexis Galarneau	162	6
SUI	Marc-Andrea Hüsler	168	7
FRA	Hugo Grenier	182	8

• ¹ Rankings are as of 31 March 2025.^[2]

The following players received wildcards into the singles main draw:

• Rodrigo Alujas
• Darwin Blanch
• Alex Hernández

The following players received entry into the singles main draw as alternates:

• Maxime Cressy
• Luka Pavlovic

The following players received entry from the qualifying draw:

• Juan Carlos Aguilar
• Andres Martin
• Maximilian Neuchrist
• Neil Oberleitner
• Alfredo Perez
• Pedro Sakamoto

The following player received entry as a lucky loser:

• Tom Paris

• Felipe Meligeni Alves def. Luka Pavlovic 6–3, 6–3.

• Santiago González / Austin Krajicek def. Ryan Seggerman / Patrik Trhac 7–6^(11–9), 3–6, [10–5].