2025 Challenger Città di Lugano

Country	Player	Rank1	Seed
BEL	Raphaël Collignon	122	1
CRO	Borna Ćorić	145	2
FRA	Luca Van Assche	152	3
BEL	Alexander Blockx	158	4
FRA	Hugo Grenier	169	5
GER	Henri Squire	179	6
LTU	Vilius Gaubas	181	7
CAN	Liam Draxl	184	8

• ¹ Rankings are as of 17 February 2025.^[1]

The following players received wildcards into the singles main draw:

• Rémy Bertola
• Mika Brunold
• Jakub Paul

The following players received entry into the singles main draw as special exempts:

• Viktor Durasovic
• Patrick Zahraj

The following player received entry into the singles main draw using a protected ranking:

• Dominic Stricker

The following players received entry into the singles main draw as alternates:

• Adrian Andreev
• Wu Tung-lin

The following players received entry from the qualifying draw:

• Ričardas Berankis
• Edas Butvilas
• Murphy Cassone
• Dino Prižmić
• Vitaliy Sachko
• Rei Sakamoto

The following players received entry as lucky losers:

• Cui Jie
• Juan Carlos Prado Ángelo

• Borna Ćorić def. Raphaël Collignon 6–3, 6–1.

• Cleeve Harper / David Stevenson def. Jakub Paul / David Pel 4–6, 6–3, [10–8].