Caroxazone

Chemical compound From Wikipedia, the free encyclopedia

Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of depression but is now no longer marketed.[2][3] It acts as a reversible monoamine oxidase inhibitor (RIMA) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter.[4][5][6][7][8]

Pregnancy
category
  • ?
Routes of
administrationOral
ATC code
  • none
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Quick facts Clinical data, Pregnancycategory ...
Caroxazone
Clinical data
Pregnancy
category
  • ?
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Identifiers
  • 2-(2-oxo-4H-1,3-benzoxazin-3-yl)acetamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.038.481 Edit this at Wikidata
Chemical and physical data
FormulaC10H10N2O3
Molar mass206.201 g·mol−1
3D model (JSmol)
  • O=C(N)CN2C(=O)Oc1ccccc1C2
Close

Synthesis

Caroxazone synthesis:[9][10][11][12][13]

Synthesis starts by reductive amination of salicylaldehyde and glycinamide to give 3. The synthesis is completed by reaction with phosgene and NaHCO3.

See also

References

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