Nitroxazepine

Nitroxazepine
Clinical data
Trade names	Sintamil
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 10-[3-(dimethylamino)propyl]-2-nitrodibenzo[b,f][1,4]oxazepin-11(10H)-one;
CAS Number	16398-39-3;
PubChem CID	27857;
ChemSpider	25919;
UNII	CNU9GY55SI;
ChEBI	CHEBI:135448;
CompTox Dashboard (EPA)	DTXSID501027193 ;
Chemical and physical data
Formula	C18H19N3O4
Molar mass	341.367 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](=O)c2ccc1Oc3c(N(C(=O)c1c2)CCCN(C)C)cccc3;
	InChI InChI=1S/C18H19N3O4/c1-19(2)10-5-11-20-15-6-3-4-7-17(15)25-16-9-8-13(21(23)24)12-14(16)18(20)22/h3-4,6-9,12H,5,10-11H2,1-2H3; Key:CGYWLLGTCBIGSR-UHFFFAOYSA-N;

Nitroxazepine (brand name Sintamil) is a tricyclic antidepressant (TCA) which was introduced by Ciba-Geigy (now Novartis) for the treatment of depression in India in 1982.^[1] It is also indicated for the treatment of nocturnal enuresis.^[1] Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor and has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.^[2]^[3]^[4]

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Clinical data

Trade names	Sintamil
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 10-[3-(dimethylamino)propyl]-2-nitrodibenzo[b,f][1,4]oxazepin-11(10H)-one
CAS Number	16398-39-3
PubChem CID	27857
ChemSpider	25919
UNII	CNU9GY55SI
ChEBI	CHEBI:135448
CompTox Dashboard (EPA)	DTXSID501027193
Chemical and physical data
Formula	C₁₈H₁₉N₃O₄
Molar mass	341.367 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [O-][N+](=O)c2ccc1Oc3c(N(C(=O)c1c2)CCCN(C)C)cccc3
InChI InChI=1S/C18H19N3O4/c1-19(2)10-5-11-20-15-6-3-4-7-17(15)25-16-9-8-13(21(23)24)12-14(16)18(20)22/h3-4,6-9,12H,5,10-11H2,1-2H3 Key:CGYWLLGTCBIGSR-UHFFFAOYSA-N