LY-88329

LY-88329
Identifiers
	IUPAC name 3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-1-phenylpropan-1-one;
CAS Number	78693-86-4;
PubChem CID	10042707;
ChemSpider	4953075;
ChEMBL	ChEMBL94345;
Chemical and physical data
Formula	C22H27NO2
Molar mass	337.463 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CCC(=O)C3=CC=CC=C3;
	InChI InChI=1S/C22H27NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h3-10,15,17,24H,11-14,16H2,1-2H3/t17-,22+/m0/s1; Key:IQGJBVSSFDCTAJ-HTAPYJJXSA-N;

LY-88329 is an opioid receptor ligand related to medicines such as pethidine. It has high affinity to the μ-opioid receptor, but unlike structurally related drugs such as 3-methylfentanyl and OPPPP, LY-88329 is a potent opioid antagonist. In animal studies it blocks the effects of morphine and has anorectic action.^[1]^[2]

References

Identifiers

IUPAC name 3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-1-phenylpropan-1-one
CAS Number	78693-86-4
PubChem CID	10042707
ChemSpider	4953075
ChEMBL	ChEMBL94345
Chemical and physical data
Formula	C₂₂H₂₇NO₂
Molar mass	337.463 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CCC(=O)C3=CC=CC=C3
InChI InChI=1S/C22H27NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h3-10,15,17,24H,11-14,16H2,1-2H3/t17-,22+/m0/s1 Key:IQGJBVSSFDCTAJ-HTAPYJJXSA-N