List of opioids
From Wikipedia, the free encyclopedia
This is a list of opioids, opioid antagonists and inverse agonists.
Opium and poppy straw derivatives
Crude opiate extracts whole opium products
Natural opiates
Opium alkaloids
Structures
| Morphides | ||||
|---|---|---|---|---|
 Codeine |
 Morphine |
 Oripavine |
 Pseudomorphine |
 Thebaine |
Alkaloid salts mixtures
- Pantopon
- Papaveretum (Omnopon)
- Tetrapon
Semisynthetics including Bentley compounds
Morphine family
- 14-Hydroxymorphine [1]
- 2,4-Dinitrophenylmorphine
- 6-Methyldihydromorphine [2]
- 6-Methylenedihydrodesoxymorphine
- 6-Acetyldihydromorphine [3]
- Azidomorphine
- Chlornaltrexamine
- Chloroxymorphamine [4]
- Desomorphine (dihydrodesoxymorphine)
- Dihydromorphine
- Ethyldihydromorphine [5][full citation needed]
- Hydromorphinol
- Methyldesorphine
- Morphine methylbromide
- N-Phenethylnordesomorphine
- N-Phenethyl-14-ethoxymetopon
- N-Phenethylnormorphine
- 6-Nicotinoyldihydromorphine (metabolite of nicodicodeine)
- RAM-378
- Ro4-1539
Structures of Morphine family
| Morphine family | ||||
|---|---|---|---|---|
 14-Hydroxymorphine |
 2,4-Dinitrophenylmorphine |
 6-Methyldihydromorphine |
 6-Methylenedihydrodesoxymorphine |
 6-Acetyldihydromorphine |
 Azidomorphine |
 Chlornaltrexamine |
 Chloroxymorphamine |
 Desomorphine (Dihydrodesoxymorphine) |
 Dihydromorphine |
 Ethyldihydromorphine |
 Hydromorphinol |
 Methyldesorphine |
 N-Phenethylnormorphine |
 6-nicotinoyldihydromorphine |
 RAM-378 | ||||
3,6-diesters of morphine
- Acetylpropionylmorphine
- 3,6-Dibutanoylmorphine
- Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
- Dibutyrylmorphine
- Dibenzoylmorphine (first designer drug)
- Diformylmorphine
- Dipropanoylmorphine
- Heroin (diacetylmorphine)
- Nicomorphine
Structures
| 3,6-diesters of morphine | ||||
|---|---|---|---|---|
 Acetylpropionylmorphine |
3,6-Dibutanoylmorphine |  Diacetyldihydromorphine(dihydroheroin, acetylmorphinol) | ||
 Dibutyrylmorphine |
 Dibenzoylmorphine |
 Diformylmorphine | ||
 Dipropanoylmorphine |
 Heroin(diacetylmorphine) |
 Nicomorphine | ||
Codeine-dionine family
- 6-Monoacetylcodeine
- Benzylmorphine
- Codeine methylbromide
- Desocodeine [permanent dead link]
- Dimethylmorphine (6-O-Methylcodeine)
- Ethyldihydromorphine [permanent dead link]
- Methyldihydromorphine (dihydroheterocodeine)
- Ethylmorphine (dionine)
- Heterocodeine
- Isocodeine
- Pholcodine (morpholinylethylmorphine)
- Myrophine
- Thebacon
- Transisocodeine
Structures
| Codeine-dionine family | ||||
|---|---|---|---|---|
 6-Monoacetylcodeine |
 Benzylmorphine |
 Codeine methylbromide |
 Desocodeine |
 Dimethylmorphine(6-O-Methylcodeine) |
| Ethyldihydromorphine |
 Methyldihydromorphine(dihydroheterocodeine) |
 Ethylmorphine |
 Heterocodeine |
 Isocodeine |
 Pholcodine |
 Myrophine |
 Transisocodeine | ||
Morphinones and morphols
- 14-Cinnamoyloxycodeinone
- 14-Ethoxymetopon
- 14-Methoxymetopon
- 14-Phenylpropoxymetopon
- 3-Acetyloxymorphone
- 3,14-Diacetyloxymorphone
- 7-Spiroindanyloxymorphone
- 8,14-Dihydroxydihydromorphinone
- Acetylcodone
- Acetylmorphone
- α-hydrocodol (=dihydrocodeine, )
- Benzhydrocodone
- Bromoisopropropyldihydromorphinone cas?
- Codeinone
- Codoxime
- Conorfone (codorphone)
- IBNtxA
- Thebacon (acetyldihydrocodeinone, dihydrocodeinone enol acetate)
- Hydrocodone
- Hydromorphone
- Hydroxycodeine
- Metopon (=methyldihydromorphinone)
- Morphenol
- Morphinone
- Morphol
- N-Phenethyl-14-ethoxymetopon
- Noroxymorphone
- Oxycodone
- Oxymorphol
- Oxymorphone
- Pentamorphone
- Semorphone
- 14-Hydroxycodeine
Structures
| Morphinones and morphols | ||||
|---|---|---|---|---|
 14-Cinnamoyloxycodeinone |
 14-Ethoxymetopon |
 14-Methoxymetopon |
 14-Phenylpropoxymetopon |
 7-Spiroindanyloxymorphone |
 8,14-Dihydroxydihydromorphinone |
 Acetylcodone |
 Acetylmorphone |
 α-hydrocodol(Dihydrocodeine) |
 Bromoisopropropyldihydromorphinone |
 Codeinone |
 Codorphone |
 Codol(Codeine Phosphate) |
 Codoxime |
 IBNtxA |
 Thebacon |
 Hydrocodone |
 Hydromorphone |
 Hydroxycodeine |
 Metopon(methyldihydromorphinone) |
 Morphenol |
 Morphinone |
 Morphol |
 N-Phenethyl-14-ethoxymetopon |
 Oxycodone |
 Oxymorphol |
 Oxymorphone |
 Pentamorphone |
 Semorphone |
|
Morphides
- α-Chlorocodide (= chlorocodide)
- β-Chlorocodide
- α-Chloromorphide (= chloromorphide)
- Bromocodide
- Bromomorphide
- Chlorodihydrocodide
- Chloromorphide
- Codide
Structures
| Morphides | ||||
|---|---|---|---|---|
 α-chlorocodide |
 β-chlorocodide |
 Bromomorphide | ||
 Chlorodihydrocodide. |
 Chloromorphide |
 Codide | ||
Dihydrocodeine series
Nitrogen morphine derivatives
- 1-Nitrocodeine cas?
- Codeine-N-oxide
- Morphine-N-oxide
Structures
| Morphides | ||||
|---|---|---|---|---|
 1-Nitrocodeine |
 Codeine-N-oxide |
 Morphine-N-oxide | ||
Hydrazones
Structures
| Hydrazones | ||||
|---|---|---|---|---|
 Oxymorphazone | ||||
Halogenated morphine derivatives
- 1-Bromocodeine
- 1-Chlorocodeine
- 1-Iodomorphine
Structures
| Other open chain opioids | ||||
|---|---|---|---|---|
1-Bromocodeine |
1-Chlorocodeine |
| ||
Active opiate metabolites
- Codeine-6-glucuronide
- Codeine-N-oxide (genocodeine)
- Heroin-7,8-oxide
- Morphine-6-glucuronide
- 3-Monoacetylmorphine
- 6-Monoacetylmorphine
- Morphine-N-oxide (genomorphine)
- Naltrexol
- Norcodeine
- Normorphine
Structures
| Active opiate metabolites | ||||
|---|---|---|---|---|
| Codeine-N-oxide |
 Heroin-7,8-oxide |
 Morphine-6-glucuronide |
 6-Monoacetylmorphine | |
| Morphine-N-oxide |
 Naltrexol |
 Norcodeine |
 Normorphine | |
Morphinans
Morphinan series
- 3-Hydroxymorphinan
- 4-Chlorophenylpyridomorphinan
- Cyclorphan
- Levargorphan
- Levorphanol
- Levophenacylmorphan
- Levomethorphan
- Methorphan (racemethorphan)
- Morphanol (racemorphanol)
- Norlevorphanol
- N-Methylmorphinan
- Oxilorphan
- Phenomorphan
- Proxorphan
- Ro4-1539
- Stephodeline [permanent dead link]Xorphanol
Structures
| Other morphinans | ||||
|---|---|---|---|---|
 4-chlorophenylpyridomorphinan |
 Cyclorphan |
 Dextrallorphan |
 Levargorphan |
 Levophenacylmorphan |
| Levomethorphan |
 Norlevorphanol |
 N-Methylmorphinan |
 Oxilorphan |
 Phenomorphan |
 Dextromethorphan levomethorphan |
 Morphanol |
 Ro4-1539 |
 Stephodeline |
 Xorphanol |
Others
- 1-Nitroaknadinine * 14-episinomenine
- 5,6-Dihydronorsalutaridine
- 6-Keto Nalbuphine
- Aknadinine
- Butorphanol
- Cephakicine
- Cephasamine
- Cyprodime
- Drotebanol
- Fenfangjine G
- Ketorfanol
- Nalbuphine
- Nalbuphone
- Tannagine
Structures
| Other Morphinans | ||||
|---|---|---|---|---|
 1-Nitroaknadinine |
 14-episinomenine |
 5,6-Dihydronorsalutaridine |
 6-Keto Nalbuphine |
 Aknadinine |
 Butorphanol |
 Cephakicine |
 Cephasamine |
 Cyprodime |
 Drotebanol |
 Fenfangjine G |
 Nalbuphine |
 Sinococuline |
 Sinomenine |
 Tannagine |
Benzomorphans
- 5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB)
- 8-Carboxamidocyclazocine (8-CAC)
- Alazocine
- Anazocine
- Bremazocine
- Butinazocine
- Carbazocine
- Cogazocine
- Cyclazocine
- Dezocine
- Eptazocine
- Etazocine [permanent dead link]
- Ethylketazocine
- Fedotozine
- Fluorophen
- Gemazocine [permanent dead link]
- Ibazocine [permanent dead link]
- Ketazocine
- Metazocine
- Moxazocine
- Pentazocine
- Phenazocine
- Quadazocine
- SKF-10047
- Tonazocine
- Volazocine
- Zenazocine
Structures
| Benzomorphans | ||||
|---|---|---|---|---|
 5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB) |
 8-Carboxamidocyclazocine |
 Alazocine |
 Anazocine |
 Bremazocine |
 Butinazocine |
 Carbazocine |
 Cogazocine |
 Cyclazocine |
 Dezocine |
 Eptazocine |
 Etazocine |
 Ethylketocyclazocine |
 Fedotozine |
 Fluorophen |
 Gemazocine |
 Ibazocine |
 Ketazocine |
 Metazocine |
 Moxazocine |
 Pentazocine |
 Phenazocine |
 Quadazocine
|
 Tonazocine | |
 Volazocine |
 Zenazocine |
|||
4-Phenylpiperidines
Pethidines (meperidines)
- 4-Fluoropethidine
- Allylnorpethidine
- Anileridine
- Benzethidine
- Carperidine
- Difenoxin
- Diphenoxylate
- Etoxeridine (carbetidine)
- Furethidine
- Hydroxypethidine (bemidone)
- Morpheridine
- Meperidine-N-oxide
- Oxpheneridine (carbamethidine)
- Pethidine (meperidine)
- Pethidine intermediate A
- Pethidine intermediate B (norpethidine)
- Pethidine intermediate C (pethidinic acid)
- Pheneridine
- Phenoperidine
- Piminodine
- Properidine (ipropethidine)
- Sameridine
Structures
Prodines
- Allylprodine
- (α/β)-Meprodine
- Desmethylprodine (MPPP)
- PEPAP
- (α/β)-Prodine
- Prosidol
- Trimeperidine (promedol)
Structures
Ketobemidones
Structures
Others
Structures
| Other phenylpiperidines | |||
|---|---|---|---|
 Alvimopan |
 Loperamide |
 LS-115509 |
 Picenadol |
Open chain opioids
Amidones
- Dextromethadone
- Dipipanone
- Dipyanone
- Isomethadone
- Levoisomethadone
- Levomethadone
- Methadone
- Methadone intermediate
- Normethadone
- Norpipanone
- Phenadoxone (heptazone)
Structures
| Amidones | ||||
|---|---|---|---|---|
|
|
|
 Levoisomethadone | |
 Noracetylmethadol |
 Levomethadone |
Methadone |
 Methadone intermediate | |
 Normethadone |
 Norpipanone |
 Phenadoxone |
 Pipidone | |
Methadols
Structures
| Other open chain opioids | ||||
|---|---|---|---|---|
|
|
|
Noracetylmethadol | |
Moramides
Structures
| Other open chain opioids | ||||
|---|---|---|---|---|
|
|
|
|
|
Thiambutenes
Structures
Phenalkoxams
- Dextropropoxyphene (propoxyphene)
- Dimenoxadol
- Dioxaphetyl butyrate
- Levopropoxyphene
- Norpropoxyphene
- Pyrroliphene
Structures
| Phenalkoxams | ||||
|---|---|---|---|---|
Dextropropoxyphene |
|
|
|
|
Ampromides
Structures
| Ampromides | ||||
|---|---|---|---|---|
|
|
| ||
Others
Structures
| Other open chain opioids | ||||
|---|---|---|---|---|
|
|
|
|
|
Anilidopiperidines
- 3-Allylfentanyl
- 3-Methylfentanyl
- 3-Methylthiofentanyl
- 4-Phenylfentanyl
- Alfentanil
- α-Methylacetylfentanyl
- α-Methylfentanyl
- α-Methylthiofentanyl
- Benzylfentanyl
- β-hydroxyfentanyl
- β-hydroxythiofentanyl
- β-Methylfentanyl
- Brifentanil
- Butyrfentanyl
- Carfentanil
- Fentanyl
- Lofentanil
- N-Methylcarfentanil
- Mirfentanil
- Ocfentanil
- Ohmefentanyl
- Parafluorofentanyl
- Phenaridine
- R-30490
- Remifentanil
- Sufentanil
- Thenylfentanyl
- Thiofentanyl
- Trefentanil
Structures
Oripavine derivatives
- 7-PET
- Acetorphine
- Alletorphine (N-allyl-noretorphine)
- BU-48
- Buprenorphine
- Buprenorphine-3-glucuronide
- Cyprenorphine
- Dihydroetorphine
- Etorphine
- Homprenorphine
- 18,19-Dehydrobuprenorphine (HS-599)
- N-cyclopropylmethylnoretorphine
- Nepenthone
- Norbuprenorphine
- Norbuprenorphine-3-glucuronide
- Thevinone
- Thienorphine
- TH-030418
Structures
| Oripavine derivatives | ||||
|---|---|---|---|---|
 7-PET |
 Acetorphine |
 Alletorphine |
 BU-48 |
 Buprenorphine |
 Cyprenorphine |
 Dihydroetorphine |
 Etorphine |
 Homprenorphine |
 18,19-Dehydrobuprenorphine |
 N-cyclopropylmethylnoretorphine |
 Nepenthone |
 Norbuprenorphine |
 Thevinone |
Thienorphine |
Phenazepanes
Structures
| Phenazepanes | ||||
|---|---|---|---|---|
|
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Pirinitramides
Structures
| Pirinitramides | ||||
|---|---|---|---|---|
|
| |||
Benzimidazoles
Structures
| Benzimidazoles | ||||
|---|---|---|---|---|
|
|
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Indoles
Structures
-Mitragynine_Structural_Formula_V1.svg)
Beta-Amino Ketones
-2,2-dimethyl-1-phenylpropan-1-one.svg)
Diphenylmethylpiperazines
Opioid peptides
Dynorphins
Structures
| Dynorphins | ||||
|---|---|---|---|---|
 Big dynorphin |
 Dynorphin A |
 Dynorphin B | ||
Endomorphins
Endorphins
Structures
Enkephalins
Structures
| Enkephalins | ||||
|---|---|---|---|---|
 DADLE |
 DAMGO |
 Deltorphin |
 Met-enkephalin |
 Leu-enkephalin |
Propeptides
Others / unknown
- Adrenorphin
- Amidorphin
- Biphalin
- Casokefamide
- Casomorphins
- Cytochrophin-4
- DALDA (Tyr-D-Arg-Phe-Lys-NH2)
- Deltorphin I
- Deltorphin II
- Deprolorphin
- Dermorphin
- DPDPE
- Frakefamide
- Gliadorphin
- Gluten exorphins
- Hemorphin-4
- Metkefamide
- Morphiceptin
- Nociceptin
- Octreotide
- Opiorphin
- Rubiscolin
- Soymorphins
- Spinorphin
- TRIMU 5
- Tynorphin
- Valorphin
- Zyklophin
Structures
| Other or unknown opioid peptides | ||||
|---|---|---|---|---|
 Adrenorphin |
 Amidorphin |
 Casomorphin |
 DALDA |
Deltorphin |
 Dermorphin |
 DPDPE |
 Endomorphin-1 Endomorphin-2 |
 Gliadorphin |
 Morphiceptin |
 Nociceptin |
 Octreotide |
 Opiorphin |
Rubiscolin |
 TRIMU 5 |
Others
- 3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane
- AD-1211
- AH-7921
- Axomadol
- Azaprocin
- BDPC
- Bisnortilidine
- BRL-52537
- Bromadol
- Bromadoline
- Ciprefadol
- Ciramadol
- Doxpicomine
- Enadoline
- Faxeladol
- GR-89696
- Herkinorin
- ICI-199,441
- ICI-204,448
- Ketamine
- KNT-42
- LPK-26
- Lufuradom
- Metofoline
- MT-45
- Desmethylclozapine
- Nexeridine
- NNC 63-0532
- Nortilidine
- O-Desmethyltramadol
- Phenadone
- Phencyclidine
- Prodilidine
- Profadol
- Ro64-6198
- Salvinorin A
- Salvinorin B ethoxymethyl ether
- Salvinorin B methoxymethyl ether
- SB-612,111
- SC-17599
- RWJ-394,674
- TAN-67
- Tapentadol
- Thiobromadol (C-8813)
- Tifluadom
- Tilidine
- Tramadol
- Trimebutine
- U-47700
- U-50,488
- U-69,593
- Viminol
- 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18)
Opioid antagonists and inverse agonists
- 4-Caffeoyl-1,5-quinide
- 5'-Guanidinonaltrindole
- β-Funaltrexamine
- 6β-Naltrexol
- 6β-Naltrexol-d4
- Alvimopan
- AT-076
- Binaltorphimine
- BU09059
- Buprenorphine
- Chlornaltrexamine
- Clocinnamox
- Cyclazocine
- Cyprodime
- Diacetylnalorphine
- Diprenorphine (M5050)
- Fedotozine
- ICI-174864
- J-113,397
- JDTic
- JTC-801
- Levallorphan
- LY-2456302
- LY-255582
- Methocinnamox
- Methylnaltrexone
- ML350
- Naldemedine
- Nalfurafine
- Nalmefene
- Nalmexone
- Nalodeine (N-allylnorcodeine)
- Naloxazone
- Naloxegol
- Naloxol
- Naloxonazine
- Naloxone
- Naloxone benzoylhydrazone
- Nalorphine
- Naltrexone
- Naltriben
- Naltrindole
- Norbinaltorphimine
- Oxilorphan
- PF-4455242
- S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)
- Samidorphan
- SR-16430
Biased ligands
Receptor heteromer targeting ligands
Uncategorized opioids
Structures
| Uncategorized opioids | ||||
|---|---|---|---|---|
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 Nalodeine |
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Combination drug formulations containing opioids
- Buprenorphine/naloxone
- Buprenorphine/samidorphan (ALKS-5461)
- Co-codamol (codeine phosphate/paracetamol)
- Co-codaprin (codeine phosphate/aspirin)
- Co-dydramol (dihydrocodeine tartrate/paracetamol)
- Co-proxamol (dextropropoxyphene/paracetamol)
- Fentanyl/fluanisone
- Hydrocodone/ibuprofen
- Hydrocodone/paracetamol
- Loperamide/simethicone
- Morphine/naltrexone
- Naltrexone/bupropion
- Oxycodone/aspirin
- Oxycodone/naloxone
- Oxycodone/paracetamol