Tissue-selective estrogen complex
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A tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator (SERM), such as tamoxifen, raloxifene, or bazedoxifene.[1] It is thought to have different tissue pattern of estrogenic and antiestrogenic effects than that of either the estrogen or the SERM alone.[1] An example of a clinically used TSEC is conjugated estrogens/bazedoxifene (brand name Duavee).[2]
- 1 2 Pickar JH, Boucher M, Morgenstern D (September 2018). "Tissue selective estrogen complex (TSEC): a review". Menopause. 25 (9): 1033–1045. doi:10.1097/GME.0000000000001095. PMC 6110370. PMID 29533367.
- ↑ Lello S, Capozzi A, Scambia G (2017). "The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause". Int J Endocrinol. 2017 5064725. doi:10.1155/2017/5064725. PMC 5735652. PMID 29358948.
| ERTooltip Estrogen receptor |
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| GPERTooltip G protein-coupled estrogen receptor |
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