2022 Uruguay Open

Country	Player	Rank1	Seed
ARG	Federico Coria	71	1
ARG	Tomás Martín Etcheverry	83	2
GER	Daniel Altmaier	91	3
ARG	Facundo Bagnis	101	4
ITA	Marco Cecchinato	109	5
ARG	Camilo Ugo Carabelli	123	6
ARG	Juan Manuel Cerúndolo	151	7
ITA	Franco Agamenone	154	8

• ¹ Rankings are as of 31 October 2022.^[1]

The following players received wildcards into the singles main draw:

• Leo Borg
• Guido Pella
• Franco Roncadelli

The following player received entry into the singles main draw using a protected ranking:

• Sumit Nagal

The following players received entry into the singles main draw as alternates:

• Nikola Milojević
• Genaro Alberto Olivieri

The following players received entry from the qualifying draw:

• Jan Choinski
• Moez Echargui
• Max Houkes
• Juan Pablo Paz
• Eduardo Ribeiro
• Federico Zeballos

The following player received entry as a lucky loser:

• Gonzalo Villanueva

• Genaro Alberto Olivieri def. Tomás Martín Etcheverry 6–7^(3–7), 7–6^(7–5), 6–3.

• Karol Drzewiecki / Piotr Matuszewski def. Facundo Díaz Acosta / Luis David Martínez 6–4, 6–4.