5-OH-DPAT

5-OH-DPAT

Names
Preferred IUPAC name (6S)-6-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Identifiers
CAS Number	68593-96-4 N
3D model (JSmol)	Interactive image Interactive image Interactive image
Abbreviations	5-OH-DPAT
ChEMBL	ChEMBL273273 N
ChemSpider	9474597 (S) Y 150564 Y
MeSH	5-Hydroxy-2-N,N-dipropylaminotetralin
PubChem CID	11299620 (S) 12280580 (R) 172267
CompTox Dashboard (EPA)	DTXSID801336109
InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1 Y Key: MDBWEQVKJDMEMK-AWEZNQCLSA-N Y
SMILES Oc1cccc2c1CC[C@H](N(CCC)CCC)C2 CCCN(CCC)C1CCc2c(O)cccc2C1 CCCN(CCC)C1CCC2=C(O)C=CC=C2C1
Properties
Chemical formula	C16H25NO
Molar mass	247.382 g·mol−1
log P	3.55
Acidity (pKa)	10.543
Basicity (pKb)	3.454
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

5-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with selectivity for the D₂ receptor and D₃ receptor subtypes.^[1][2] Only the (S)-enantiomer is active as an agonist, with the (R)-enantiomer being a weak antagonist at D₂ receptors.^[3] Radiolabelled ¹¹C-5-OH-DPAT is used as an agonist radioligand for mapping the distribution and function of D₂ and D₃ receptors in the brain,^[4][5] and the drug is also being studied in the treatment of Parkinson's disease.^{[6][needs update]}