PF-219,061
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Chemical compound
Pharmaceutical compound
Legal status
- Investigational (discontinued)
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| Routes of administration | Nasal |
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| Formula | C13H19NO2 |
| Molar mass | 221.300 g·mol−1 |
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PF-219,061 is a drug that was under development by Pfizer which acts as a potent and highly selective agonist for the dopamine D3 receptor.[1][2] It was under development as a potential medication for the treatment of female sexual dysfunction.[3][4] It did not advance into clinical trials.[5]
References
- ↑ Blagg J, Allerton CM, Batchelor DV, Baxter AD, Burring DJ, Carr CL, et al. (December 2007). "Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route". Bioorganic & Medicinal Chemistry Letters. 17 (24): 6691–6. doi:10.1016/j.bmcl.2007.10.059. PMID 17976986.
- ↑ Brioni JD, Moreland RB (2006). "Dopamine D4 receptors and the regulation of penile erection". Drug Discovery Today: Therapeutic Strategies. 3 (4): 599–604. doi:10.1016/j.ddstr.2006.10.006.
- ↑ Van Der Graaf et al. Selective Dopamine D3 Receptor Agonists for the Treatment of Sexual Dysfunction, WIPO Patent WO2003051370, granted to Pfizer
- ↑ Attkins NJ, Heatherington AC, Phipps J, Verrier H, Huyghe I (July 2009). "Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 39 (7): 523–33. doi:10.1080/00498250902893775. PMID 19480558. S2CID 26474660.
- ↑ Cortés A, Moreno E, Rodríguez-Ruiz M, Canela EI, Casadó V (July 2016). "Targeting the dopamine D3 receptor: an overview of drug design strategies". Expert Opinion on Drug Discovery. 11 (7): 641–64. doi:10.1080/17460441.2016.1185413. PMID 27135354. S2CID 205917989.