77-LH-28-1

CAS Number

• 560085-11-2

PubChem CID

• 10236758

IUPHAR/BPS

• 3271

ChemSpider

• 8412246

77-LH-28-1

Identifiers
IUPAC name 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one
CAS Number	560085-11-2
PubChem CID	10236758
IUPHAR/BPS	3271
ChemSpider	8412246
UNII	9ZH28BM589
CompTox Dashboard (EPA)	DTXSID90437063
Chemical and physical data
Formula	C21H32N2O
Molar mass	328.500 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC
InChI InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3 Key:PHMGZAICAOYEAF-UHFFFAOYSA-N

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M₁) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M₁ over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects.^[1] It has been used as a lead compound for discovery of other M1 agonists, and a crystal structure of the bound complex between 77-LH-28-1 and the M1 receptor has been published.^[2]