Benactyzine

Benactyzine is an anticholinergic drug that was used in the treatment of clinical depression and anxiety disorders before it was pulled from the U.S. market by the FDA due to serious side effects.^[2]

AHFS/Drugs.comInternational Drug Names

Routes of
administrationOral

ATC code

• none

Legal status

• BR: Class C1 (Other controlled substances)^[1]
• In general: ℞ (Prescription only)

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Benactyzine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	BR: Class C1 (Other controlled substances)[1] In general: ℞ (Prescription only)
Identifiers
IUPAC name 2-(diethylamino)ethyl hydroxy(diphenyl)acetate
CAS Number	302-40-9 Y
PubChem CID	9330
DrugBank	DB09023 N
ChemSpider	8966 Y
UNII	595EG71R3F
KEGG	D07498 Y
ChEMBL	ChEMBL70352 Y
CompTox Dashboard (EPA)	DTXSID0022644
ECHA InfoCard	100.005.568
Chemical and physical data
Formula	C20H25NO3
Molar mass	327.424 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OCCN(CC)CC)C(O)(c1ccccc1)c2ccccc2
InChI InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3 Y Key:IVQOFBKHQCTVQV-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects.^[2] "Large doses of benactyzine in normal subjects may produce a state resembling the action of mescaline or LSD."^[3]

Brand names have included: Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan. While there was some tentative evidence of effectiveness when combined with meprobamate, with the medication no longer available it is not clinically important.^[4]