COPE (gene)

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PDBOrtholog search: PDBe RCSB
AliasesCOPE, epsilon-COP, coatomer protein complex subunit epsilon, COPI coat complex subunit epsilon
COPE
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPE, epsilon-COP, coatomer protein complex subunit epsilon, COPI coat complex subunit epsilon
External IDsOMIM: 606942; MGI: 1891702; HomoloGene: 5254; GeneCards: COPE; OMA:COPE - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007263
NM_199442
NM_199444
NM_001330469
NM_025088

NM_021538

RefSeq (protein)

NP_001317398
NP_009194
NP_955474
NP_955476

NP_067513

Location (UCSC)Chr 19: 18.9 – 18.92 MbChr 8: 70.76 – 70.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.[5][6]

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

Interactions

COPE (gene) has been shown to interact with COPA.[7][8][9]

References

Further reading

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