MiR-144
Family of microRNA precursors
From Wikipedia, the free encyclopedia
miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.
| miR-144 | |
|---|---|
Conserved secondary structure of miR-144 precursor microRNA | |
| Identifiers | |
| Symbol | miR-144 |
| Alt. Symbols | MIR144 |
| Rfam | RF00682 |
| miRBase | MI0000460 |
| miRBase family | MIPF0000093 |
| NCBI Gene | 406936 |
| HGNC | 31531 |
| OMIM | 612070 |
| RefSeq | NR_029685 |
| Other data | |
| RNA type | miRNA |
| Domain | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 17 q11.2 |
| PDB structures | PDBe |
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]
Function
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]
Applications
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]