2025 Open de Rennes

Country	Player	Rank1	Seed
FRA	Hugo Gaston	125	1
SUI	Stan Wawrinka	146	2
FRA	Harold Mayot	152	3
FRA	Titouan Droguet	159	4
FRA	Calvin Hemery	185	5
FRA	Sascha Gueymard Wayenburg	206	6
ITA	Federico Cinà	210	7
FRA	Arthur Bouquier	215	8

• ¹ Rankings are as of 25 August 2025.^[1]

The following players received wildcards into the singles main draw:

• Sean Cuenin
• Daniel Jade
• Maé Malige

The following players received entry into the singles main draw as alternates:

• Grégoire Barrère
• Vadym Ursu

The following players received entry from the qualifying draw:

• Enzo Couacaud
• Kenny de Schepper
• Maxime Janvier
• Cannon Kingsley
• Leo Raquillet
• Nikolay Vylegzhanin

The following players received entry as lucky losers:

• Robin Catry
• Egor Gerasimov

• Hugo Gaston def. Stan Wawrinka 6–4, 6–4.

• Patrik Niklas-Salminen / Matěj Vocel def. Hendrik Jebens / Albano Olivetti 6–3, 6–3.