2025 Antofagasta Challenger

Country	Player	Rank1	Seed
USA	Emilio Nava	90	1
CHI	Cristian Garín	124	2
BOL	Hugo Dellien	126	3
CHI	Tomás Barrios Vera	133	4
ITA	Francesco Maestrelli	154	5
LBN	Hady Habib	172	6
AUT	Lukas Neumayer	175	7
ARG	Alex Barrena	188	8

¹ Rankings are as of 22 September 2025.^[1]

The following players received wildcards into the singles main draw:

• Facundo Bagnis
• Daniel Antonio Núñez
• Benjamín Torrealba

The following players received entry into the singles main draw as alternates:

• Pedro Boscardin Dias
• Facundo Díaz Acosta

The following players received entry from the qualifying draw:

• Joaquín Aguilar Cardozo
• Luciano Emanuel Ambrogi
• Franco Roncadelli
• Juan Bautista Torres
• Gonzalo Villanueva
• Carlos María Zárate

The following player received entry as a lucky loser:

• Aristotelis Thanos

• Cristian Garín def. Facundo Díaz Acosta 2–6, 6–3, 6–3.

• Gonzalo Escobar / Miguel Ángel Reyes-Varela def. Luís Britto / Matheus Pucinelli de Almeida 6–3, 4–6, [10–6].