GRIK4
From Wikipedia, the free encyclopedia
| glutamate receptor, ionotropic, kainate 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GRIK4 | ||||||
| Alt. symbols | GRIK, KA1 | ||||||
| NCBI gene | 2900 | ||||||
| HGNC | 4582 | ||||||
| OMIM | 600282 | ||||||
| RefSeq | NM_014619 | ||||||
| UniProt | Q16099 | ||||||
| Other data | |||||||
| Locus | Chr. 11 q | ||||||
| |||||||
| GRIK4 3 prime UTR element | |
|---|---|
 Secondary structure identified in the 3' UTR of the GRIK4 transcript | |
| Identifiers | |
| Symbol | GRIK4_3p_UTR |
| Rfam | RF01383 |
| Other data | |
| RNA type | Gene; |
| Domain(s) | Eukaryota; |
| SO | SO:0001263 |
| PDB structures | PDBe |
GRIK4 (glutamate receptor, ionotropic, kainate 4) is a kainate receptor subtype belonging to the family of ligand-gated ion channels which is encoded by the GRIK4 gene.[1]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2]
Clinical significance
A single nucleotide polymorphism (rs1954787) in the GRIK4 gene has shown a treatment-response-association with antidepressant treatment.[3]
Variation in GRIK4 have been associated with both increased and decreased risk of bipolar disorder.[4] A possible mechanism for this observation is that the sequence variation influences secondary structures in the 3' UTR.
Interfering with GRIK4/KA1 function with a specific anti-KA1 antibody protects against kainate-induced neuronal cell death.[5][6]
A test of that gene can be made in order to know if a depressed patient will respond to the SSRI citalopram.[3][7]