2025 Champaign Challenger

Country	Player	Rank1	Seed
COL	Nicolás Mejía	208	1
GBR	Johannus Monday	212	2
USA	Mitchell Krueger	236	3
USA	Murphy Cassone	245	4
GER	Mats Rosenkranz	261	5
USA	Andres Martin	269	6
GEO	Saba Purtseladze	288	7
USA	Tyler Zink	299	8

• ¹ Rankings are as of November 3, 2025.^[1]

The following players received wildcards into the singles main draw:

• Sasha Colleu
• Ádám Jilly
• Oliver Okonkwo

The following player received entry into the singles main draw using a protected ranking:

• Micah Braswell

The following player received entry into the singles main draw through the Junior Accelerator programme:

• Roh Ho-young

The following player received entry into the singles main draw as an alternate:

• Adhithya Ganesan

The following players received entry from the qualifying draw:

• Taym Al Azmeh
• Ryan Fishback
• Pablo Martínez Gómez
• Lui Maxted
• Shunsuke Mitsui
• Jeremy Zhang

The following player received entry as a lucky loser:

• Quinn Vandecasteele

• Stefan Kozlov def. Murphy Cassone 7–6^(7–3), 7–5.

• Patrick Harper / Shunsuke Mitsui def. Ryan Seggerman / Keegan Smith 7–5, 6–7^(3–7), [12–10].