2025 Challenger Seguros del Estado

Country	Player	Rank1	Seed
ARG	Juan Pablo Ficovich	164	1[2]
COL	Nicolás Mejía	212	2
MEX	Rodrigo Pacheco Méndez	216	3
KAZ	Dmitry Popko	227	4
ARG	Santiago Rodríguez Taverna	235	5
BOL	Murkel Dellien	265	6
USA	Garrett Johns	279	7
USA	Stefan Kozlov	306	8

• ¹ Rankings are as of 17 November 2025.^[3]

The following players received wildcards into the singles main draw:

• Samuel Heredia
• Samuel Alejandro Linde Palacios
• Salvador Price

The following player received entry into the singles main draw as an alternate:

• Miguel Tobón

The following players received entry from the qualifying draw:

• Nicolás Barrientos
• Peter Bertran
• Ryan Dickerson
• Juan Sebastián Gómez
• Alan Magadán
• Karl Poling

The following player received entry as a lucky loser:

• Gerard Campaña Lee

• Nicolás Mejía def. Juan Sebastián Gómez 6–4, 6–4.

• Luis David Martínez / Cristian Rodríguez def. Nicolás Barrientos / Benjamin Kittay 6–1, 6–4.