Kenazepine
From Wikipedia, the free encyclopedia
 | |
| Clinical data | |
|---|---|
| Trade names | Kenazepine |
| Other names | Acetamide |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider |
|
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C19H16BrClFN3O2 |
| Molar mass | 452.71 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
 N Y (what is this?) | |
Kenazepine is a benzodiazepine containing a functional alkylating moiety.[1] The chemical formula is C19H16BrClFN3O2.[2]
The compound functions as a research tool in pharmacology. It binds irreversibly and non-competitively to some brain benzodiazepine receptors and competitively to others, providing evidence for the existence of different receptor populations within the central nervous system. Kenazepine exhibits long-lasting anticonvulsant effects, likely due to its irreversible binding mechanism, and is used to study the heterogeneity and function of benzodiazepine receptors.[3]
Studies show that kenazepine provides a long-lasting protection against convulsions caused by pentylenetetrazole in vivo, suggesting a similar irreversible binding mechanism in the body.[2]
References
- ↑ Skolnick P, Paul SM (1982). Benzodiazepine Receptors in the Central Nervous System. International Review of Neurobiology. Vol. 23. pp. 103–140 (115). doi:10.1016/S0074-7742(08)60623-6. ISBN 978-0-12-366823-3. PMID 6288605.
Kenazepine , a derivative of the benzodiazepine Ro 7/1986 has a bromoacetyl moiety that can react with binucleophiles such as SH and - NH2.
- 1 2 Williams EF, Rice KC, Mattson M, Paul SM, Skolnick P (April 1981). "In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine". Pharmacology, Biochemistry, and Behavior. 14 (4): 487–91. doi:10.1016/0091-3057(81)90307-5. PMID 7232472.
- ↑ Williams EF, Rice KC, Paul SM, Skolnick P (1980). "Heterogeneity of Benzodiazepine Receptors in the Central Nervous System Demonstrated with Kenazepine, an Alkylating Benzodiazepine". Journal of Neurochemistry. 35 (3): 591–597. doi:10.1111/j.1471-4159.1980.tb03695.x. ISSN 1471-4159. PMID 6256492. Retrieved 14 September 2025.