Minaxolone

Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed.^[1][2][3] It is a positive allosteric modulator of the GABA_A receptor,^[4] as well as, less potently, a positive allosteric modulator of the glycine receptor.^[4][5]

Other names11α-(Dimethylamino)-2β-ethoxy-3α-hydroxy-5α-pregnan-20-one

ATC code

• none

CAS Number

• 62571-87-3 ^Y

PubChem CID

• 71960

Quick facts Clinical data, Other names ...

Minaxolone

Clinical data
Other names	11α-(Dimethylamino)-2β-ethoxy-3α-hydroxy-5α-pregnan-20-one
ATC code	none
Identifiers
IUPAC name 1-[(1S,2S,4S,5S,7S,10S,11S,14S,15S,17R)-17-(dimethylamino)-4-ethoxy-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]ethan-1-one
CAS Number	62571-87-3 Y
PubChem CID	71960
IUPHAR/BPS	5478
ChemSpider	64967 N
UNII	737SKC73L0
KEGG	D05041 Y
ChEMBL	ChEMBL2105209 N
CompTox Dashboard (EPA)	DTXSID201024283
Chemical and physical data
Formula	C25H43NO3
Molar mass	405.623 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCO[C@H]1C[C@]2([C@@H](CC[C@@H]3[C@@H]2[C@@H](C[C@]4([C@H]3CC[C@@H]4C(=O)C)C)N(C)C)C[C@@H]1O)C
InChI InChI=1S/C25H43NO3/c1-7-29-22-14-24(3)16(12-21(22)28)8-9-17-19-11-10-18(15(2)27)25(19,4)13-20(23(17)24)26(5)6/h16-23,28H,7-14H2,1-6H3/t16-,17-,18+,19-,20+,21-,22-,23+,24-,25+/m0/s1 N Key:NCGLTZSBTFVVAW-KNXRZYMVSA-N N
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