NS-2710

CAS Number

• 184220-36-8 ^Y

PubChem CID

• 9863520

ChemSpider

• 8039216

UNII

• J0WHC91NJO

NS-2710

Identifiers
IUPAC name 1-[1-[3-(3-pyridyl)phenyl]benzimidazol-5-yl]ethanone O-ethyloxime
CAS Number	184220-36-8 Y
PubChem CID	9863520
ChemSpider	8039216
UNII	J0WHC91NJO
ChEMBL	ChEMBL381625
Chemical and physical data
Formula	C22H20N4O
Molar mass	356.429 g·mol−1
3D model (JSmol)	Interactive image
SMILES c4ncccc4-c(c2)cccc2-n3c1ccc(cc1nc3)C(C)=NOCC
InChI InChI=1S/C22H20N4O/c1-3-27-25-16(2)17-9-10-22-21(13-17)24-15-26(22)20-8-4-6-18(12-20)19-7-5-11-23-14-19/h4-15H,3H2,1-2H3/b25-16+ Key:NHJFEXZXSCFYRX-PCLIKHOPSA-N
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NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABA_A receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide,^[1] and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence.^[2]