JWH-398

JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It has mild selectivity for CB₁ with a K_i of 2.3 nM and 2.8 nM at CB₂.^[2] This synthetic chemical compound was identified by the EMCDDA as an ingredient in three separate "herbal incense" products purchased from online shops between February and June 2009.^[3] It was discovered by, and named after, John W. Huffman.^[4]

Legal status

• CA: Schedule II
• DE: NpSG (Industrial and scientific use only)
• UK: Class B
• US: Schedule I
• Illegal in Latvia^[1]

CAS Number

• 1292765-18-4 ^N

ChemSpider

• 28647395 ^N

UNII

• RX0E95S90H

Quick facts Legal status, Identifiers ...

JWH-398

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B US: Schedule I Illegal in Latvia[1]
Identifiers
IUPAC name 1-Pentyl-3-(4-chloro-1-naphthoyl)indole
CAS Number	1292765-18-4 N
ChemSpider	28647395 N
UNII	RX0E95S90H
CompTox Dashboard (EPA)	DTXSID40156131
Chemical and physical data
Formula	C24H22ClNO
Molar mass	375.90 g·mol−1
3D model (JSmol)	Interactive image
SMILES c14ccccc1n(CCCCC)cc4C(=O)c(cc3)c2ccccc2c3Cl
InChI InChI=1S/C24H22ClNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3 N Key:IUWBHGFOHXVVKV-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Close

In the United States, JWH-398 is a Schedule I controlled substance.^[5]