PS75

PS75 is an experimental analgesic drug which acts as a functionally selective alpha-2A (α_2A) adrenergic agonist, with a K_i of 8.2nM and an EC₅₀ of 4.8nM at the α_2A-adrenergic receptor. In animal studies it was found to produce analgesia but without the sedation typical of older drugs acting at this target such as dexmedetomidine. While PS75 itself is unlikely to be developed for medical use, the successful separation of analgesia from sedative effects makes it likely that related compounds may be developed as non-sedating, non-opioid analgesic medications.^[1]

ATC code

• None

CAS Number

• 2925328-43-2 ^Y

FormulaC₁₅H₁₁ClN₂

Molar mass254.72 g·mol⁻¹

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PS75

Clinical data
ATC code	None
Identifiers
IUPAC name N-(pyridin-4-yl)-7-chloronaphthalen-1-amine
CAS Number	2925328-43-2 Y
Chemical and physical data
Formula	C15H11ClN2
Molar mass	254.72 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1cc2c(cccc2cc1)Nc1ccncc1

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