2021 Campeonato Internacional de Tênis de Campinas

Country	Player	Rank1	Seed
ARG	Federico Coria	70	1
ESP	Jaume Munar	89	2
ARG	Juan Manuel Cerúndolo	91	3
BRA	Thiago Monteiro	95	4
URU	Pablo Cuevas	97	5
COL	Daniel Elahi Galán	102	6
ARG	Sebastián Báez	111	7
ARG	Francisco Cerúndolo	112	8

• ¹ Rankings as of 8 November 2021.^[1]

The following players received wildcards into the singles main draw:

• Matheus Bueres
• Gustavo Heide
• Gilbert Klier Júnior

The following players received entry into the singles main draw as alternates:

• Orlando Luz
• Matheus Pucinelli de Almeida

The following players received entry from the qualifying draw:

• Nicolás Álvarez
• Nicolás Álvarez Varona
• Johan Nikles
• Santiago Rodríguez Taverna

• Sebastián Báez def. Thiago Monteiro 6–1, 6–4.

• Rafael Matos / Felipe Meligeni Alves def. Gilbert Klier Júnior / Matheus Pucinelli de Almeida 6–3, 6–1.