2021 Nur-Sultan Challenger

Country	Player	Rank1	Seed
KAZ	Mikhail Kukushkin	90	1
RUS	Evgeny Donskoy	123	2
GER	Cedrik-Marcel Stebe	129	3
IND	Prajnesh Gunneswaran	131	4
SUI	Henri Laaksonen	139	5
AUT	Jurij Rodionov	152	6
SVK	Martin Kližan	158	7
SLO	Blaž Rola	159	8

• ¹ Rankings are as of 15 February 2021.^[1]

The following players received wildcards into the singles main draw:

• Timofey Skatov
• Dostanbek Tashbulatov
• Denis Yevseyev

The following players received entry into the singles main draw as alternates:

• Ulises Blanch
• Wu Tung-lin

The following players received entry from the qualifying draw:

• Bogdan Bobrov
• Pavel Kotov
• Vladyslav Manafov
• Ryan Peniston

The following players received entry as lucky losers:

• Ivan Nedelko
• Roberto Quiroz

• Mackenzie McDonald def. Jurij Rodionov 6–1, 6–2.

• Denys Molchanov / Aleksandr Nedovyesov def. Nathan Pasha / Max Schnur 6–4, 6–4.